# Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats.
> 水素水が放射線誘発性認知障害に与える影響：脳組織メタボロミクスと生物学的ネットワーク解析による機序の解明


## Abstract

Using a rat model of ionizing radiation-induced cognitive impairment, this study examined the pharmacological mechanisms of hydrogen-rich water (HRW) through combined brain tissue metabolomics and biological target network approaches. HRW administration led to significant improvement in cognitive function. Integrated analysis identified 54 differentially expressed metabolites and 93 target genes. KEGG pathway mapping highlighted glutathione metabolism, ascorbic acid and aldehyde acid metabolism, pentose and glucuronic acid interconversion, and glycerophospholipid metabolism as key pathways involved in the protective response. These findings provide a systematic molecular framework for understanding how HRW modulates metabolite levels, biological targets, and signaling pathways to counteract radiation-induced cognitive decline.

### Mechanism

HRW is proposed to alleviate radiation-induced cognitive impairment by modulating 54 differential metabolites and 93 target genes through pathways including glutathione metabolism, glycerophospholipid metabolism, and ascorbic acid-related metabolism.

## Bibliographic

- **Authors**: Liu X, Liu M, Liu H, Yuan HB, Wang Y, Chen X, et al.
- **Journal**: BMC Mol Cell Biol
- **Year**: 2023 (2023-09-26)
- **PMID**: [37752412](https://pubmed.ncbi.nlm.nih.gov/37752412/)
- **DOI**: [10.1186/s12860-023-00491-4](https://doi.org/10.1186/s12860-023-00491-4)
- **PMC**: [PMC10523633](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523633/)
- **Study type**: animal study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 37752412. https://h2-papers.org/en/papers/37752412
> **Source**: PubMed PMID [37752412](https://pubmed.ncbi.nlm.nih.gov/37752412/)