# Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study.
> 慢性肺疾患患者における水素水摂取と酸素飽和度の関連：非無作為化観察パイロット研究


## Abstract

Ten patients with chronic lung diseases—including COPD (n=7), bronchial asthma (n=2), and pulmonary tuberculosis (n=1)—presenting with oxygen saturation between 90% and 95% consumed high-concentration hydrogen-rich water (>5 mM) generated via H2-producing tablets over a 4-week period. Compared to baseline, SpO2 increased significantly, while oxidative stress markers including TBARS, MDA, and diene conjugates declined. Vitamin E and nitrite levels rose concurrently. Physical training conducted following the hydrogen-rich water intervention appeared to further improve exercise tolerance and reduce hypoxia, potentially delaying the need for supplemental oxygen. The authors conclude that further controlled research is warranted to confirm these preliminary findings.

### Mechanism

Hydrogen-rich water appears to reduce lipid peroxidation markers (TBARS, MDA, diene conjugates) and elevate antioxidant levels (vitamin E) along with nitrite, suggesting that attenuation of oxidative stress may underlie the observed improvements in oxygen saturation in chronic lung disease.

## Bibliographic

- **Authors**: Singh RB, Tarnava A, Fatima G, Fedacko J, Mojto V, LeBaron TW
- **Journal**: Diseases
- **Year**: 2023 (2023-09-26)
- **PMID**: [37873771](https://pubmed.ncbi.nlm.nih.gov/37873771/)
- **DOI**: [10.3390/diseases11040127](https://doi.org/10.3390/diseases11040127)
- **PMC**: [PMC10594520](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594520/)
- **Study type**: human observational study
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 37873771. https://h2-papers.org/en/papers/37873771
> **Source**: PubMed PMID [37873771](https://pubmed.ncbi.nlm.nih.gov/37873771/)