# Molecular Hydrogen: Emerging Treatment for Stroke Management.
> 脳卒中管理における分子状水素の役割：新たなアプローチとしての可能性


## Abstract

Ischemic stroke remains a leading global cause of mortality and long-term disability, with approved interventions limited to mechanical thrombectomy and intravenous thrombolysis. Molecular hydrogen has attracted growing research interest due to its antioxidative, anti-inflammatory, and antiapoptotic properties, which may be relevant to stroke pathophysiology. Multiple delivery routes have been examined in preclinical and clinical settings, including inhalation of hydrogen gas, intravenous or intraperitoneal administration of hydrogen-enriched solutions, and oral intake of hydrogen-enriched water. This review synthesizes available evidence on the underlying mechanisms, safety profiles, and efficacy outcomes associated with molecular hydrogen in the context of stroke, and discusses potential refinements in dosing, duration, and administration route for future investigation.

### Mechanism

Molecular hydrogen is proposed to protect ischemic brain tissue by selectively scavenging reactive oxygen species, suppressing inflammatory signaling via NF-κB, and inhibiting apoptotic pathways, thereby reducing neuronal damage following stroke.

## Bibliographic

- **Authors**: Kuo HC, Chen KD, Li PY
- **Journal**: Chem Res Toxicol
- **Year**: 2023 (2023-12-18)
- **PMID**: [37988743](https://pubmed.ncbi.nlm.nih.gov/37988743/)
- **DOI**: [10.1021/acs.chemrestox.3c00259](https://doi.org/10.1021/acs.chemrestox.3c00259)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 37988743. https://h2-papers.org/en/papers/37988743
> **Source**: PubMed PMID [37988743](https://pubmed.ncbi.nlm.nih.gov/37988743/)