# Acute effect of hydrogen-rich water on physical, perceptual and cardiac responses during aerobic and anaerobic exercises: a randomized, placebo-controlled, double-blinded cross-over trial.
> 水素水の急性摂取が有酸素・無酸素運動における身体・知覚・心臓応答に与える影響：無作為化二重盲検クロスオーバー試験


## Abstract

This randomized, double-blind, placebo-controlled crossover study enrolled 22 male amateur middle-distance runners who consumed 500 mL of hydrogen-rich water (HRW) or placebo 30 minutes before exercise testing across 4 days. Aerobic assessments included the Vameval maximal aerobic speed (MAS) test and a time-to-exhaustion (Tlim) protocol, while anaerobic capacity was evaluated via squat jump (SJ), counter-movement jump (CMJ), and five-jump test (5JT). HRW ingestion was associated with improvements in peak heart rate (HRpeak) and rating of perceived exertion (RPE) during both aerobic tests, and Tlim was also extended compared with placebo. However, no statistically significant differences between HRW and placebo were detected for SJ, CMJ, or 5JT performance. These findings suggest that acute HRW consumption may selectively benefit aerobic endurance indices and perceptual responses without meaningfully altering explosive anaerobic output in amateur runners.

### Mechanism

Molecular hydrogen dissolved in water is proposed to selectively scavenge reactive oxygen species generated during exercise, thereby reducing oxidative stress and improving cardiorespiratory and perceptual responses during aerobic effort.

## Bibliographic

- **Authors**: Jebabli N, Ouerghi N, Abassi W, Yagin FH, Khlifi M, Boujabli M, et al.
- **Journal**: Front Physiol
- **Year**: 2023
- **PMID**: [38162831](https://pubmed.ncbi.nlm.nih.gov/38162831/)
- **DOI**: [10.3389/fphys.2023.1240871](https://doi.org/10.3389/fphys.2023.1240871)
- **PMC**: [PMC10757640](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10757640/)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: mixed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 38162831. https://h2-papers.org/en/papers/38162831
> **Source**: PubMed PMID [38162831](https://pubmed.ncbi.nlm.nih.gov/38162831/)