# Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing.
> 固体原子水素による広域RONS消去と糖尿病性創傷治癒促進


## Abstract

Tungsten bronze phase HWO (HWO) was identified as a solid-state hydrogen carrier capable of releasing atomic hydrogen in a temperature-dependent manner, exhibiting broad-spectrum scavenging of reactive oxygen and nitrogen species (RONS) distinct from molecular hydrogen. The material also displays pH-responsive biodegradability, enabling clearance from pathological sites after use. In a diabetic wound animal model, HWO administration promoted M2-type macrophage polarization and anti-inflammatory cytokine production, which in turn stimulated vascular formation and accelerated chronic wound closure. These findings broaden the known categories of hydrogen-based therapeutic materials and support investigation of diverse physical forms of hydrogen as RONS scavengers.

### Mechanism

Atomic hydrogen released from HWO scavenges a broad spectrum of RONS, promotes M2-type macrophage polarization and anti-inflammatory cytokine production, and thereby stimulates angiogenesis to accelerate diabetic wound closure.

## Bibliographic

- **Authors**: Luo M, Wang Q, Zhao GD, Jiang W, Zeng C, Zhang Q, et al.
- **Journal**: Natl Sci Rev
- **Year**: 2024
- **PMID**: [38213516](https://pubmed.ncbi.nlm.nih.gov/38213516/)
- **DOI**: [10.1093/nsr/nwad269](https://doi.org/10.1093/nsr/nwad269)
- **PMC**: [PMC10776359](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776359/)
- **Study type**: animal study
- **Delivery route**: topical application
- **Effect reported**: positive

## Delivery context

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 38213516. https://h2-papers.org/en/papers/38213516
> **Source**: PubMed PMID [38213516](https://pubmed.ncbi.nlm.nih.gov/38213516/)