# Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis.
> 健康成人における運動誘発性酸化ストレスに対する水素補給の効果：系統的レビューとメタ解析


## Abstract

A systematic review and meta-analysis was performed to quantitatively evaluate how H2 supplementation affects exercise-induced oxidative stress in healthy adults. Six studies comprising seven experiments and 76 participants were identified from five databases. Three delivery forms were examined: hydrogen-rich water, hydrogen bathing, and hydrogen-rich gas, administered at varying time points relative to exercise. Pooled analysis showed no significant difference between H2 and placebo for the oxidative stress marker d-ROMs (SMD = −0.01, 95% CI −0.42 to 0.39). In contrast, biological antioxidant potential (BAP) was significantly greater in the H2 group (SMD = 0.29, 95% CI 0.04 to 0.54). Subgroup analysis further indicated that antioxidant capacity improvements were more pronounced during intermittent exercise (SMD = 0.52, 95% CI 0.16 to 0.87) than during continuous exercise. These findings suggest H2 supplementation enhances antioxidant capacity rather than directly reducing oxidative stress markers, though larger and more rigorously designed trials are needed to confirm these conclusions.

### Mechanism

H2 selectively scavenges excess free radicals, thereby enhancing biological antioxidant potential (BAP). However, direct reduction of oxidative stress as measured by d-ROMs was not demonstrated in pooled analysis.

## Bibliographic

- **Authors**: Li Y, Bing R, Liu M, Shang Z, Huang Y, Zhou KW, et al.
- **Journal**: Front Nutr
- **Year**: 2024
- **PMID**: [38590828](https://pubmed.ncbi.nlm.nih.gov/38590828/)
- **DOI**: [10.3389/fnut.2024.1328705](https://doi.org/10.3389/fnut.2024.1328705)
- **PMC**: [PMC10999621](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999621/)
- **Study type**: meta-analysis
- **Delivery route**: mixed routes
- **Effect reported**: mixed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 38590828. https://h2-papers.org/en/papers/38590828
> **Source**: PubMed PMID [38590828](https://pubmed.ncbi.nlm.nih.gov/38590828/)