# Mesenchymal Stem Cell Priming: Potential Benefits of Administration of Molecular Hydrogen.
> 間葉系幹細胞プライミングにおける分子状水素の潜在的有用性に関するレビュー


## Abstract

Mesenchymal stem cells (MSCs) have attracted considerable research interest owing to their distinctive biological properties and broad applicability in regenerative contexts. This review examines the concept of MSC priming with molecular hydrogen (H2) as a strategy to augment cell-based regenerative approaches. The authors discuss how H2 exposure prior to or during MSC administration may improve key cellular attributes, including viability, differentiation capacity, and anti-inflammatory signaling. The review synthesizes current evidence suggesting that H2-mediated priming could represent a practical and low-risk method for optimizing MSC performance across a range of degenerative diseases and tissue injuries, thereby broadening the translational potential of MSC-based regenerative strategies.

### Mechanism

H2 priming is proposed to enhance MSC function by reducing oxidative stress, modulating anti-inflammatory signaling pathways, and preserving mitochondrial integrity, collectively improving cell viability and differentiation potential.

## Bibliographic

- **Authors**: Artamonov M, LeBaron TW, Pyatakovich FA, Minenko IA
- **Journal**: Pharmaceuticals (Basel)
- **Year**: 2024 (2024-04-07)
- **PMID**: [38675429](https://pubmed.ncbi.nlm.nih.gov/38675429/)
- **DOI**: [10.3390/ph17040469](https://doi.org/10.3390/ph17040469)
- **PMC**: [PMC11054387](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11054387/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 38675429. https://h2-papers.org/en/papers/38675429
> **Source**: PubMed PMID [38675429](https://pubmed.ncbi.nlm.nih.gov/38675429/)