# Crystal structure and Hirshfeld surface analysis of 5-hy-droxy-penta-nehydrazide.
> 5-ヒドロキシペンタンヒドラジドの結晶構造およびHirshfeld表面解析


## Abstract

This study reports the synthesis and structural characterization of 5-hydroxypentanehydrazide, an aliphatic carboxyhydrazide compound prepared by reacting a lactone with hydrazine hydrate. Colorless prismatic single crystals were obtained and found to belong to the orthorhombic space group P2. Supramolecular analysis revealed medium-to-strong intermolecular hydrogen bonding interactions involving both the hydroxyl and hydrazide functional groups. Three-dimensional crystal packing was further examined using Hirshfeld surface analysis and fingerprint plots, which identified weak H···H and C···H contacts. The compound is noted as a potential intermediate for derivatives capable of inhibiting Mycobacterium tuberculosis catalase-peroxidase (KatG), thereby contributing to pathogen elimination.

### Mechanism

The compound's hydroxyl and hydrazide moieties can be derivatized to yield analogs that inhibit Mycobacterium tuberculosis catalase-peroxidase (KatG), potentially leading to pathogen death.

## Bibliographic

- **Authors**: Justen GA, Carneiro Neto JS, Sousa Santana F, Leiriane Batistel Ribas M, Gomes da Silva de Paula F, Dario PP, et al.
- **Journal**: Acta Crystallogr E Crystallogr Commun
- **Year**: 2024 (2024-04-01)
- **PMID**: [38721432](https://pubmed.ncbi.nlm.nih.gov/38721432/)
- **DOI**: [10.1107/S2056989024002871](https://doi.org/10.1107/S2056989024002871)
- **PMC**: [PMC11074568](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074568/)
- **Study type**: other
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 38721432. https://h2-papers.org/en/papers/38721432
> **Source**: PubMed PMID [38721432](https://pubmed.ncbi.nlm.nih.gov/38721432/)