# Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial.
> 高尿酸血症患者における水素水摂取が血中尿酸値に及ぼす影響：無作為化プラセボ対照試験


## Abstract

A randomized, placebo-controlled trial enrolled 100 patients with hyperuricemia, divided into three groups: placebo (ordinary water, 3×330 mL/day), low-dose hydrogen-rich water (HRW; 2×330 mL HRW with H₂ ≥4.66 mg/L plus 1×330 mL ordinary water/day), and high-dose HRW (3×330 mL HRW/day), each for 8 weeks. Blood uric acid was measured at baseline, 4 weeks, and 8 weeks. After 8 weeks, the high-dose group showed a statistically significant decline in uric acid from 488.2±54.1 μmol/L to 446.8±57.1 μmol/L (p<0.05), with a greater magnitude of reduction compared to the low-dose group. No notable safety concerns were identified. These results suggest that sustained, higher-dose HRW consumption may offer a feasible approach to managing elevated uric acid levels.

### Mechanism

The authors attribute the uric acid-lowering effect to the anti-inflammatory and metabolic-modulatory properties of dissolved molecular hydrogen, though the precise biochemical pathway was not investigated in this trial.

## Bibliographic

- **Authors**: Wu F, Ma J, Xue J, Jiang X, Liu J, Zhang JH, et al.
- **Journal**: Heliyon
- **Year**: 2024 (2024-08-30)
- **PMID**: [39258191](https://pubmed.ncbi.nlm.nih.gov/39258191/)
- **DOI**: [10.1016/j.heliyon.2024.e36401](https://doi.org/10.1016/j.heliyon.2024.e36401)
- **PMC**: [PMC11385766](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11385766/)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 39258191. https://h2-papers.org/en/papers/39258191
> **Source**: PubMed PMID [39258191](https://pubmed.ncbi.nlm.nih.gov/39258191/)