# Stereocontrolled Hydrogenation of Conjugated Enones to Alcohols via Dual Iridium-Catalysis.
> 二重イリジウム触媒を用いた共役エノンの立体制御的水素化によるアルコール合成


## Abstract

This study reports a one-pot dual iridium-catalyzed approach for converting conjugated enones into saturated alcohols with precise stereocontrol, using molecular hydrogen as the sole reductant for both reduction steps. Two distinct iridium catalyst classes—N,P-iridium (selective for olefin reduction) and NHC,P-iridium (selective for ketone reduction)—functioned independently without mutual interference. This orthogonal catalytic system enabled the construction of two adjacent stereocenters with enantioselectivity up to 99% ee and diastereoselectivity of 99/1 d.r. By simply varying the chirality of either ligand set, all four possible stereoisomers of the target saturated alcohol were accessible in equally high stereopurity. The method demonstrated broad substrate scope across alkyl-, aryl-, and heteroaryl-substituted enones, highlighting the wide applicability of this dual-catalysis concept.

### Mechanism

N,P-iridium catalysts selectively hydrogenate the olefin moiety while NHC,P-iridium catalysts independently reduce the ketone moiety, both using molecular hydrogen, enabling sequential construction of two contiguous stereocenters in a single pot.

## Bibliographic

- **Authors**: Zheng J, Peters BBC, Mallick RK, Andersson PG
- **Journal**: Angew Chem Int Ed Engl
- **Year**: 2025 (2025-01-15)
- **PMID**: [39320171](https://pubmed.ncbi.nlm.nih.gov/39320171/)
- **DOI**: [10.1002/anie.202415171](https://doi.org/10.1002/anie.202415171)
- **Study type**: other
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 39320171. https://h2-papers.org/en/papers/39320171
> **Source**: PubMed PMID [39320171](https://pubmed.ncbi.nlm.nih.gov/39320171/)