# Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training.
> 水素水の8日間摂取がレジスタンストレーニング中の筋持久力パフォーマンスおよび疲労回復に与える影響


## Abstract

This randomized, double-blinded, placebo-controlled crossover trial enrolled 18 resistance-trained men (mean age 19.7 ± 0.9 years) to evaluate whether intermittent hydrogen-rich water (HRW) intake influences muscular endurance and recovery following resistance exercise. Participants consumed 1,920 mL of HRW or placebo water daily for 7 days, with an additional 1,260 mL distributed across five time points on the training day. The exercise protocol consisted of six sets of half-squats at 70% of one-repetition maximum performed to failure. HRW supplementation was associated with significantly greater total power output (50,866.7 ± 6,359.9 W vs. 46,431.0 ± 9,376.5 W; p = 0.032) and total repetitions completed (78.2 ± 9.5 vs. 70.3 ± 9.5; p = 0.019) relative to placebo. Countermovement jump height, subjective recovery scale scores, and muscle soreness ratings did not differ significantly between conditions at any post-exercise time point (immediately, 24 h, or 48 h). These findings indicate that 8-day HRW supplementation can enhance muscular endurance capacity in trained individuals, though it may not sufficiently accelerate subjective fatigue or soreness recovery after high-intensity resistance sessions.

### Mechanism

Molecular hydrogen is proposed to reduce exercise-induced oxidative stress and inflammatory responses through its antioxidant and anti-inflammatory properties, thereby preserving muscular function during repeated high-intensity efforts.

## Bibliographic

- **Authors**: Zhou KW, Yuan C, Shang Z, Jiao W, Wang Y
- **Journal**: Front Physiol
- **Year**: 2024
- **PMID**: [39434721](https://pubmed.ncbi.nlm.nih.gov/39434721/)
- **DOI**: [10.3389/fphys.2024.1458882](https://doi.org/10.3389/fphys.2024.1458882)
- **PMC**: [PMC11491356](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491356/)
- **Study type**: human randomized controlled trial
- **Delivery route**: hydrogen-rich water
- **Effect reported**: mixed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 39434721. https://h2-papers.org/en/papers/39434721
> **Source**: PubMed PMID [39434721](https://pubmed.ncbi.nlm.nih.gov/39434721/)