# Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report.
> 慢性合併症を有する高齢患者における分子状水素摂取による腎機能改善および疲労軽減の可能性：症例報告


## Abstract

An 89-year-old woman with a history of coronary artery bypass grafting, type 2 diabetic nephropathy, and systemic lupus erythematosus (SLE) was evaluated after initiating adjunctive molecular hydrogen capsule intake in January 2023. Over the observation period, serum creatinine levels declined, indicating an improvement in renal function. Chronic fatigue, quantified with the Taiwan Brief Fatigue Inventory (BFI-T), showed notable improvement. Immunological parameters underwent a series of changes, pointing to immune modulation as a plausible underlying mechanism. The patient had also presented with recurrent cellulitis at a saphenous vein donor site that showed limited response to antibiotics. This case suggests that oral molecular hydrogen supplementation may confer benefits across multiple organ systems in elderly individuals carrying complex chronic comorbidities, and highlights the need for controlled clinical investigations to confirm these observations.

### Mechanism

Molecular hydrogen is proposed to exert antioxidant and anti-inflammatory effects that modulate immune responses, potentially contributing to reductions in oxidative stress-driven renal damage and systemic fatigue in the context of chronic autoimmune and metabolic disease.

## Bibliographic

- **Authors**: Lin Y, Lu J, Ho YJ, Lui SW, Hsieh TY, Wang K, et al.
- **Journal**: In Vivo
- **Year**: 2025
- **PMID**: [39740897](https://pubmed.ncbi.nlm.nih.gov/39740897/)
- **DOI**: [10.21873/invivo.13862](https://doi.org/10.21873/invivo.13862)
- **PMC**: [PMC11705128](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705128/)
- **Study type**: human case report
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 39740897. https://h2-papers.org/en/papers/39740897
> **Source**: PubMed PMID [39740897](https://pubmed.ncbi.nlm.nih.gov/39740897/)