# New possibilities of the prevention and treatment of cardiovascular pathologies. the potential of molecular hydrogen in the reduction of oxidative stress and its consequences.
> 心血管病態における酸化ストレス軽減への分子状水素の可能性：新たな予防・介入アプローチ


## Abstract

An imbalance between reactive oxygen species (ROS) generation and the body's antioxidant defenses underlies oxidative stress, which is recognized as a shared pathological mechanism in cardiovascular diseases, aging, and cognitive impairment. When free radical production—arising from partial oxygen reduction—exceeds cellular antioxidant capacity, damage to lipids, proteins, DNA, and RNA ensues, accompanied by inflammation and cellular degeneration. Conventional antioxidants have shown limited efficacy in clinical settings. Molecular hydrogen (H2) offers a distinct advantage: it selectively neutralizes hydroxyl radicals (·OH), the most reactive ROS, while leaving physiologically necessary ROS intact for normal cell signaling. This review examines the physicochemical basis of H2's antioxidant selectivity and its potential relevance to cardiovascular pathologies and related oxidative stress conditions.

### Mechanism

H2 selectively scavenges hydroxyl radicals (·OH) without eliminating physiologically essential ROS, thereby reducing oxidative damage to lipids, proteins, and nucleic acids and attenuating downstream inflammatory responses in cardiovascular and related pathologies.

## Bibliographic

- **Authors**: Slezák J, Ravingerová T, Kura B
- **Journal**: Physiol Res
- **Year**: 2024 (2024-12-31)
- **PMID**: [39808170](https://pubmed.ncbi.nlm.nih.gov/39808170/)
- **DOI**: [10.33549/physiolres.935491](https://doi.org/10.33549/physiolres.935491)
- **PMC**: [PMC11827053](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827053/)
- **Study type**: review
- **Delivery route**: not specified
- **Effect reported**: not assessed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 39808170. https://h2-papers.org/en/papers/39808170
> **Source**: PubMed PMID [39808170](https://pubmed.ncbi.nlm.nih.gov/39808170/)