# Molecular hydrogen: Mechanism against oxidative stress and application in periodontitis: A review.
> 分子状水素の酸化ストレス抑制メカニズムと歯周炎への応用：レビュー


## Abstract

This review examines the mechanisms by which molecular hydrogen mitigates oxidative stress and evaluates its potential role in periodontitis management. Given the growing demand for antioxidant strategies in clinical dentistry, the authors survey existing evidence on hydrogen's effects in periodontal contexts and outline future research directions. Using periodontitis as a case study, the review introduces an Essence-Necessity-Feasibility-Practice (ENFP) framework for assessing whether novel antioxidant agents warrant clinical adoption. Specific considerations are offered regarding hydrogen application at each phase of periodontal surgical procedures.

### Mechanism

Molecular hydrogen selectively neutralizes highly reactive oxygen species, particularly hydroxyl radicals and peroxynitrite, thereby reducing oxidative damage without disrupting physiological redox signaling.

## Bibliographic

- **Authors**: Ying J, Zhang K, Huang Y, Zhu XQ, Ruan Y, Lin HY, et al.
- **Journal**: Medicine (Baltimore)
- **Year**: 2025 (2025-03-07)
- **PMID**: [40068089](https://pubmed.ncbi.nlm.nih.gov/40068089/)
- **DOI**: [10.1097/MD.0000000000041800](https://doi.org/10.1097/MD.0000000000041800)
- **PMC**: [PMC11902952](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902952/)
- **Study type**: review
- **Delivery route**: mixed routes
- **Effect reported**: not assessed

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 40068089. https://h2-papers.org/en/papers/40068089
> **Source**: PubMed PMID [40068089](https://pubmed.ncbi.nlm.nih.gov/40068089/)