# Hydrogen and Methane Detection in Breath in Response to Two Different Types of Dietary Fiber and Its Relationship to Postprandial Glucose Concentration in Obese Patients with Type 2 Diabetes and Normoglycemic Subjects.
> 2型糖尿病患者および正常血糖者における食物繊維摂取後の呼気水素・メタン産生と食後血糖値との関連


## Abstract

This study examined 14 patients with type 2 diabetes mellitus (T2DM) and 14 normoglycemic controls using two dietary fiber challenge tests (inulin and guar gum), with simultaneous measurement of exhaled hydrogen (H2) and methane (CH4) alongside continuous flash glucose monitoring. All normoglycemic subjects showed a significant rise in exhaled H2 after fiber intake, whereas T2DM patients demonstrated markedly lower H2 production (OR 0.17, 95% CI 0.031–0.93, p = 0.043). An inverse correlation was identified between peak postprandial glucose elevation and peak exhaled H2 in the normoglycemic group (r = −0.569, p = 0.034). Conversely, T2DM patients exhibited positive correlations between exhaled CH4 levels and postprandial glycemic parameters during the lactulose test. These findings suggest that reduced intestinal H2 production and elevated CH4 generation may be mechanistically linked to more pronounced postprandial hyperglycemia, potentially identifying novel targets for glycemic management in T2DM.

### Mechanism

Reduced intestinal bacterial H2 production and elevated CH4 generation appear to correlate with greater postprandial hyperglycemia, suggesting that gut microbial gas metabolism may influence postprandial glucose regulation in T2DM.

## Bibliographic

- **Authors**: Misnikova I, Kovaleva Y, Shokur S, LeBaron TW, Povarova O, Medvedev OS
- **Journal**: Nutrients
- **Year**: 2025 (2025-03-06)
- **PMID**: [40077785](https://pubmed.ncbi.nlm.nih.gov/40077785/)
- **DOI**: [10.3390/nu17050917](https://doi.org/10.3390/nu17050917)
- **PMC**: [PMC11902166](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902166/)
- **Study type**: human observational study
- **Delivery route**: not specified
- **Effect reported**: mixed

## Delivery context

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

The delivery route is not clearly identifiable from this paper. For hydrogen intake, inhalation is the most efficient route; inhalation, however, carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 40077785. https://h2-papers.org/en/papers/40077785
> **Source**: PubMed PMID [40077785](https://pubmed.ncbi.nlm.nih.gov/40077785/)