# Corrigendum to "Protective effect of hydrogen-rich water on spermatogenesis in high-fat diet obese rats" [Toxicology and Applied Pharmacology Volume 499, June 2025, 117334].
> 高脂肪食肥満ラットの精子形成に対する水素水の保護効果に関する正誤表


## Abstract

This publication is a corrigendum to an original article examining the protective effects of hydrogen-rich water on spermatogenesis in rats rendered obese through a high-fat diet, previously published in Toxicology and Applied Pharmacology (Volume 499, June 2025, article 117334). The notice provides corrections to the original manuscript. No new experimental data are presented in this erratum.

## Bibliographic

- **Authors**: Rigi MH, Asghari SZ, Eshtad E, Nazari SE, Aminian A, Kharazmi K, et al.
- **Journal**: Toxicol Appl Pharmacol
- **Year**: 2025
- **PMID**: [40311701](https://pubmed.ncbi.nlm.nih.gov/40311701/)
- **DOI**: [10.1016/j.taap.2025.117356](https://doi.org/10.1016/j.taap.2025.117356)
- **Study type**: other
- **Delivery route**: hydrogen-rich water
- **Effect reported**: not assessed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

---

> **Cite as**: H2 Papers — PMID 40311701. https://h2-papers.org/en/papers/40311701
> **Source**: PubMed PMID [40311701](https://pubmed.ncbi.nlm.nih.gov/40311701/)