# Acid-triggered ultralong hydrogen release from AB-loaded hollow mesoporous silica nanoparticles enhances salt tolerance in sweetpotato.
> 中空メソポーラスシリカナノ粒子に封入したアンモニアボランによる酸応答性長時間水素放出がサツマイモの塩耐性を向上させる


## Abstract

Soil salinization poses a major constraint on global crop productivity. This study developed a nanoscale hydrogen-releasing material, AB@HMSN, by encapsulating ammonia borane (AB) within hollow mesoporous silica nanoparticles (HMSN). The material achieved an AB loading capacity of 811 mg per gram of HMSN and sustained acid-triggered hydrogen release for up to 75 hours, far exceeding conventional hydrogen-rich water. Application of 16 mg/L AB@HMSN to sweetpotato (Ipomoea batatas) seedlings under 150 mM NaCl stress increased chlorophyll a, b, and total chlorophyll by 80%, 100%, and 88%, respectively, and improved photosynthetic rate, stomatal conductance, and transpiration rate by 53%, 26%, and 24%. Antioxidant enzyme activities (SOD, POD, CAT) were elevated and reactive oxygen species accumulation was reduced. Mechanistic analysis indicated that AB@HMSN stimulated endogenous melatonin biosynthesis, which in turn activated Na+/H+ antiporters and plasma membrane H+-ATPase, restoring ion homeostasis through coordinated Na+ efflux, K+ influx, and H+ influx.

### Mechanism

AB@HMSN induces endogenous melatonin production, which activates Na+/H+ antiporters and plasma membrane H+-ATPase, promoting Na+ efflux and K+ influx to restore ion homeostasis under salt stress.

## Bibliographic

- **Authors**: Xia N, Zhuang Z, Wang Q, Pan Z, Yu Y, Li Z, et al.
- **Journal**: J Biotechnol
- **Year**: 2025
- **PMID**: [40651661](https://pubmed.ncbi.nlm.nih.gov/40651661/)
- **DOI**: [10.1016/j.jbiotec.2025.07.008](https://doi.org/10.1016/j.jbiotec.2025.07.008)
- **Study type**: other
- **Delivery route**: in vitro
- **Effect reported**: positive

## Delivery context

This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 40651661. https://h2-papers.org/en/papers/40651661
> **Source**: PubMed PMID [40651661](https://pubmed.ncbi.nlm.nih.gov/40651661/)