# Hydrogen-Rich Water Consumption for Acute and Residual Fatigue After Simulated Football Matches: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Parallel Trial.
> 模擬サッカー試合後の急性・残存疲労に対する水素水摂取の効果：無作為化二重盲検プラセボ対照並行試験プロトコル


## Abstract

Football match play generates both acute fatigue—observable immediately after competition—and residual fatigue persisting up to 72 hours, driven by the sport's intermittent high-intensity demands including sprints, accelerations, and physical contacts. This registered protocol describes a randomized, double-blind, placebo-controlled, parallel-group trial in elite junior football players designed to evaluate pre-exercise hydrogen-rich water (HRW) consumption versus placebo. Primary outcomes include repeated sprint ability and countermovement jump performance as neuromuscular indices, while creatine kinase levels and visual analog scale-rated muscle soreness serve as metabolic and perceptual markers. Assessments are scheduled immediately post warm-up, directly after the simulated match, and at 24, 48, and 72 hours during recovery. Data collection is planned to begin in August 2025, with results anticipated for publication by late 2025 or the first half of 2026. The investigators hypothesize that molecular hydrogen's antioxidative properties may reduce muscle damage markers and accelerate neuromuscular recovery, potentially improving readiness for subsequent high-intensity training.

### Mechanism

Molecular hydrogen is proposed to exert antioxidative effects that reduce exercise-induced oxidative stress, thereby attenuating muscle damage markers such as creatine kinase and facilitating neuromuscular recovery.

## Bibliographic

- **Authors**: Hruby M, Hulka K, Bernatik D
- **Journal**: JMIR Res Protoc
- **Year**: 2025 (2025-07-22)
- **PMID**: [40694834](https://pubmed.ncbi.nlm.nih.gov/40694834/)
- **DOI**: [10.2196/69744](https://doi.org/10.2196/69744)
- **PMC**: [PMC12326158](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326158/)
- **Study type**: other
- **Delivery route**: hydrogen-rich water
- **Effect reported**: not assessed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 40694834. https://h2-papers.org/en/papers/40694834
> **Source**: PubMed PMID [40694834](https://pubmed.ncbi.nlm.nih.gov/40694834/)