# Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.
> 空洞埋め込み型二重円錐マイクロニードルを用いた乾癬への経皮的水素送達システムの開発


## Abstract

Psoriasis is a chronic inflammatory skin condition driven by a self-reinforcing cycle of oxidative stress and immune dysregulation. Conventional topical agents face barriers from limited skin permeability and systemic side-effect risks. In this study, a double-conical microneedle device with embedded cavities was engineered to carry MgH₂ powders and achieve sustained intracutaneous release of molecular hydrogen. In a murine psoriasis model, the system outperformed calcipotriol cream—a standard-of-care topical agent—by substantially reducing oxidative tissue damage, pro-inflammatory cytokine levels, immune cell infiltration, keratinocyte hyperproliferation, and systemic manifestations. Mechanistic analyses clarified how the oxidative stress–inflammation axis perpetuates psoriatic pathology. The findings establish a microneedle-based transdermal platform as a viable strategy for delivering molecular hydrogen to inflammatory skin conditions.

### Mechanism

MgH₂ embedded in microneedles releases molecular hydrogen within skin tissue, selectively scavenging reactive oxygen species and interrupting the mutually reinforcing oxidative stress–inflammation cycle, thereby suppressing keratinocyte hyperproliferation and immune cell infiltration.

## Bibliographic

- **Authors**: Zhu D, Lim RYD, Poh YL, Li DZ, Raghavan S, Chen P
- **Journal**: J Control Release
- **Year**: 2025 (2025-12-10)
- **PMID**: [41083007](https://pubmed.ncbi.nlm.nih.gov/41083007/)
- **DOI**: [10.1016/j.jconrel.2025.114313](https://doi.org/10.1016/j.jconrel.2025.114313)
- **Study type**: animal study
- **Delivery route**: topical application
- **Effect reported**: positive

## Delivery context

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

## Safety notes

Topical applications have localized-effect reports, but systemic hydrogen intake is most efficient via inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — PMID 41083007. https://h2-papers.org/en/papers/41083007
> **Source**: PubMed PMID [41083007](https://pubmed.ncbi.nlm.nih.gov/41083007/)