# Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report.
> 内頸動脈閉塞による虚血性脳卒中に対する水素・ロジオラ併用の補助的使用：症例報告


## Abstract

A 68-year-old male with paroxysmal atrial fibrillation developed right internal carotid artery (ICA) occlusion presenting as left hemiplegia (NIHSS 12, mRS 5). Endovascular thrombectomy failed (mTICI 0), and superficial temporal artery to middle cerebral artery bypass surgery was performed. Daily molecular hydrogen-rhodiola capsule administration was initiated postoperatively. Over six months, motor strength in the affected limbs recovered from Medical Research Council grade 1 to grade 5. Serial immunological monitoring revealed progressive increases in type 1 regulatory T (Tr1) cells and regulatory B cells, along with elevated TIM-3 expression on cytotoxic T cells. Steroid discontinuation was achieved without relapse, and no adverse events were recorded. The findings suggest that this adjunctive regimen may support neurovascular recovery through immune modulation.

### Mechanism

Molecular hydrogen's antioxidant and anti-inflammatory properties may have promoted immune regulation by increasing type 1 regulatory T cells and regulatory B cells while enhancing TIM-3 expression on cytotoxic T cells, potentially facilitating neurovascular recovery.

## Bibliographic

- **Authors**: Chang FH, Lu J, Hu CJ, Jheng WL, Ka SM, Lin S, et al.
- **Journal**: Open Med (Wars)
- **Year**: 2025
- **PMID**: [41141928](https://pubmed.ncbi.nlm.nih.gov/41141928/)
- **DOI**: [10.1515/med-2025-1290](https://doi.org/10.1515/med-2025-1290)
- **PMC**: [PMC12552863](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12552863/)
- **Study type**: human case report
- **Delivery route**: hydrogen-rich water
- **Effect reported**: positive

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 41141928. https://h2-papers.org/en/papers/41141928
> **Source**: PubMed PMID [41141928](https://pubmed.ncbi.nlm.nih.gov/41141928/)