# Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway.
> cGAS-STING経路の抑制を介した水素による乾癬様皮膚炎症の改善


## Abstract

Psoriasis is a chronic immune-mediated condition marked by keratinocyte hyperproliferation and dysregulated cytokine signaling. This study investigated the molecular basis by which hydrogen-rich water exerts its effects in psoriasis-like skin inflammation. The cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway was found to be activated in psoriatic lesions, and hydrogen administration markedly suppressed this pathway in both cell-based and mouse model experiments. Concurrently, expression of proliferative markers BCL2, BAX, and Ki-67 was reduced following hydrogen exposure. Reactive oxygen species levels and inflammatory cytokine production were also significantly diminished. These findings identify cGAS-STING pathway inhibition as a key mechanism underlying hydrogen's modulatory effects on keratinocyte proliferation and skin inflammation in psoriasis models.

### Mechanism

Hydrogen-rich water inhibits the cGAS-STING signaling pathway, thereby reducing keratinocyte hyperproliferation and suppressing ROS generation along with inflammatory cytokine production in psoriasis-like inflammation.

## Bibliographic

- **Authors**: Wu Y, Wang X, Sun YP, Duan Y, Zhang MH, Sang H, et al.
- **Journal**: Clin Exp Immunol
- **Year**: 2026 (2026-01-06)
- **PMID**: [41533764](https://pubmed.ncbi.nlm.nih.gov/41533764/)
- **DOI**: [10.1093/cei/uxaf081](https://doi.org/10.1093/cei/uxaf081)
- **PMC**: [PMC12803025](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12803025/)
- **Study type**: animal study
- **Delivery route**: mixed routes
- **Effect reported**: positive

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 41533764. https://h2-papers.org/en/papers/41533764
> **Source**: PubMed PMID [41533764](https://pubmed.ncbi.nlm.nih.gov/41533764/)