# Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
> ケイ酸マグネシウムナノシートによる持続的水素放出が脳内出血後の二次性脳損傷を軽減する


## Abstract

Intracerebral hemorrhage (ICH) causes severe secondary brain injury through oxidative stress, neuroinflammation, and apoptosis. This study synthesized pH-responsive magnesium silicate nanosheets (MGNs) capable of sustained hydrogen release, especially under acidic conditions. In a collagenase-induced ICH mouse model, oral MGN administration produced dose-dependent improvements in neurological function, reductions in brain edema and hematoma volume, preservation of neuronal integrity, suppression of pro-inflammatory cytokines, and decreased apoptotic signaling. MGNs outperformed conventional 3% hydrogen gas inhalation in neuroprotective efficacy and demonstrated a favorable biosafety profile across systematic evaluation. These findings position MGNs as a promising nanoplatform for sustained hydrogen delivery in the context of hemorrhagic brain injury.

### Mechanism

MGNs release hydrogen continuously under acidic conditions, suppressing neuronal apoptotic pathways and reducing pro-inflammatory cytokine production, thereby mitigating secondary brain injury following ICH.

## Bibliographic

- **Authors**: Ma C, Han B, Guo J, Shi CK, Liu Y, Yi WJ, et al.
- **Journal**: J Transl Med
- **Year**: 2026 (2026-02-07)
- **PMID**: [41654898](https://pubmed.ncbi.nlm.nih.gov/41654898/)
- **DOI**: [10.1186/s12967-026-07755-5](https://doi.org/10.1186/s12967-026-07755-5)
- **PMC**: [PMC12977831](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977831/)
- **Study type**: animal study
- **Delivery route**: mixed routes
- **Effect reported**: positive
- **H2 concentration**: 3%

## Delivery context

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 41654898. https://h2-papers.org/en/papers/41654898
> **Source**: PubMed PMID [41654898](https://pubmed.ncbi.nlm.nih.gov/41654898/)