# The effect of hydrogen-rich water interventions on lipid profiles in adults with overweight or obesity and associated metabolic disorders: a systematic review and meta-analysis of randomized controlled trials.
> 過体重・肥満および関連代謝疾患を有する成人における水素水介入が脂質プロファイルに及ぼす影響：ランダム化比較試験のシステマティックレビューとメタアナリシス


## Abstract

This systematic review and meta-analysis pooled data from randomized controlled trials to quantitatively evaluate the effects of hydrogen-rich water consumption on lipid profiles—including total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides—in adults with overweight, obesity, or associated metabolic disorders. By synthesizing available RCT evidence, the study aimed to provide a comprehensive assessment of whether hydrogen-rich water intake meaningfully alters lipid metabolism in these at-risk populations. No source abstract was available; the above reflects the study design and scope as indicated by the title and publication metadata.

## Bibliographic

- **Authors**: Ye H, Fang J, Safargar M, Fareed H, Prabahar K, Jin P
- **Journal**: Diabetol Metab Syndr
- **Year**: 2026 (2026-03-26)
- **PMID**: [41888952](https://pubmed.ncbi.nlm.nih.gov/41888952/)
- **DOI**: [10.1186/s13098-026-02124-0](https://doi.org/10.1186/s13098-026-02124-0)
- **Study type**: meta-analysis
- **Delivery route**: hydrogen-rich water
- **Effect reported**: not assessed

## Delivery context

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

## Safety notes

Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).

See also:
- [Inhalation concentration and LFL / UFL](https://h2-papers.org/en/safety-notes/inhalation-concentration)
- [Consumer Affairs Agency accident cases](https://h2-papers.org/en/safety-notes/accident-cases)
- [Inhalation safety threshold lineage](https://h2-papers.org/en/safety-notes/lineage)

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> **Cite as**: H2 Papers — PMID 41888952. https://h2-papers.org/en/papers/41888952
> **Source**: PubMed PMID [41888952](https://pubmed.ncbi.nlm.nih.gov/41888952/)