# Evidence base for hydrogen baths and topical applications

Evidence on hydrogen bathing and localized applications. Systemic hydrogen uptake is most efficient via inhalation.

## Related papers (28)

- [An Iron-Scavenging and Hydrogen-Releasing Microneedle Patch Suppresses Ferroptosis and Promotes Spinal Cord Repair.](/en/papers/41960786) — ACS Nano 2026 — topical application — positive
- [Local Visible-Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer.](/en/papers/40491331) — Adv Sci (Weinh) 2025 — topical application — positive
- [Coaxial Fibrous Dressing Enabling Sequential NO/HRelease for Temporally Programmed Antibacterial and Healing-Promoting Functions in Infected Diabetic Wound Treatment.](/en/papers/40504663) — ACS Appl Mater Interfaces 2025 — topical application — positive
- [Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study.](/en/papers/40563361) — Antioxidants (Basel) 2025 — topical application — positive
- [Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.](/en/papers/41083007) — J Control Release 2025 — topical application — positive
- [Efficacy of different nasal irrigation treatments versus placebo in allergic rhinitis: a systematic review and network meta-analysis.](/en/papers/41293244) — Front Pharmacol 2025 — topical application — mixed
- [Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing.](/en/papers/38213516) — Natl Sci Rev 2024 — topical application — positive
- [Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries.](/en/papers/36529921) — Curr Top Med Chem 2023 — topical application — not assessed
- [Two-Dimensional MgSi Nanosheet-Enabled Sustained Hydrogen Generation for Improved Repair and Regeneration of Deeply Burned Skin.](/en/papers/36546774) — Adv Healthc Mater 2023 — topical application — positive
- [Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis.](/en/papers/37391861) — Exp Dermatol 2023 — hydrogen bath — positive
- [Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.](/en/papers/34854419) — Med Gas Res 2022 — hydrogen bath — positive
- [Symbiotic Algae-Bacteria Dressing for Producing Hydrogen to Accelerate Diabetic Wound Healing.](/en/papers/34928162) — Nano Lett 2022 — topical application — positive
- [Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound Healing by Activating Antioxidant Activity in a Rat Alkali Burn Model.](/en/papers/36077171) — Int J Mol Sci 2022 — topical application — positive
- [Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing.](/en/papers/36167814) — Nat Commun 2022 — topical application — positive
- [Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial.](/en/papers/33356580) — Res Sports Med 2021 — hydrogen bath — null
- [Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans.](/en/papers/33454037) — J Therm Biol 2021 — hydrogen bath — positive
- [Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.](/en/papers/32399209) — F1000Res 2020 — hydrogen bath — positive
- [An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal Epithelial Cells by Molecular Hydrogen, Leading to the Suppression of Alkali-Induced Oxidative Stress.](/en/papers/32655773) — Oxid Med Cell Longev 2020 — topical application — positive
- [The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise.](/en/papers/33123594) — J Sports Med (Hindawi Publ Corp) 2020 — hydrogen bath — positive
- [The Efficacy of Melanin Precursor QIAPI 1© Against Age-related Macular Degeneration (AMD): A Case Report.](/en/papers/33167844) — Cent Nerv Syst Agents Med Chem 2020 — topical application — mixed
- [Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen Generation Powder.](/en/papers/33419292) — Int J Mol Sci 2020 — topical application — positive
- [Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.](/en/papers/31249254) — Med Gas Res 2019 — hydrogen bath — mixed
- [Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete.](/en/papers/32595937) — F1000Res 2019 — topical application — positive
- [Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress.](/en/papers/28400915) — Oxid Med Cell Longev 2017 — topical application — positive
- [Accelerated healing of full thickness dermal wounds by macroporous waterborne polyurethane-chitosan hydrogel scaffolds.](/en/papers/28887957) — Mater Sci Eng C Mater Biol Appl 2017 — topical application — positive
- [Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and corneal photodamage.](/en/papers/29269749) — Sci Rep 2017 — topical application — positive
- [A novel method of preserving cardiac grafts using a hydrogen-rich water bath.](/en/papers/23273745) — J Heart Lung Transplant 2013 — hydrogen bath — positive
- [Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury.](/en/papers/19834032) — Invest Ophthalmol Vis Sci 2010 — topical application — positive

## Related safety notes

- [/safety-notes/inhalation-concentration](/en/safety-notes/inhalation-concentration)
- [/safety-notes/accident-cases](/en/safety-notes/accident-cases)

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> **Cite as**: H2 Papers — https://h2-papers.org/en/topics/bath/evidence