H₂
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immune modulation
180 papers
Delivery-method distribution
hydrogen-rich water: 61
mixed routes: 33
inhalation: 29
not specified: 20
in vitro: 17
injection / infusion: 10
topical application: 4
animal model: 4
hydrogen bath: 2
Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice.
2026 ・ Life Sci ・ PMID 42105975
inhalation
positive
animal study
Effects of Inhalation of Hydrogen Gas on Allergic Conjunctivitis Model Mice.
2026 ・ J Ocul Pharmacol Ther ・ PMID 42101321
inhalation
positive
animal study
Consumption of hydrogen-rich water ameliorates atherosclerosis by modulating gut microbiota and enhancing short-chain fatty acid levels.
2026 ・ Life Sci ・ PMID 42069299
hydrogen-rich water
positive
animal study
Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.
2026 ・ In Vivo ・ PMID 42049414
hydrogen-rich water
positive
human case report
Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.
2026 ・ Int Immunopharmacol ・ PMID 42035551
mixed routes
positive
animal study
Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.
2026 ・ In Vivo ・ PMID 41760342
hydrogen-rich water
positive
human case report
Exploratory Evaluation of Hydrogen-Rich Water Therapy for Keloid Management: A Double-Blinded Randomized Pilot Trial.
2026 ・ Aesthetic Plast Surg ・ PMID 41545661
hydrogen-rich water
positive
human randomized controlled trial
Hydrogen ameliorates psoriasis-like skin inflammation via inhibiting the cGAS-STING pathway.
2026 ・ Clin Exp Immunol ・ PMID 41533764
mixed routes
positive
animal study
Medical Gases as Emerging Regulators of Paediatric Endocrine and Neurodevelopmental Pathways: A Mini-Review.
2026 ・ Acta Paediatr ・ PMID 41482991
not specified
not assessed
review
Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.
2026 ・ In Vivo ・ PMID 41482402
hydrogen-rich water
positive
human case report
Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.
2026 ・ In Vivo ・ PMID 41482388
hydrogen-rich water
positive
human case report
Osteoimmunometabolic modulation via hydrogen-self-supplying magnesium-reinforced collagen membrane for enhanced guided bone regeneration.
2026 ・ Biomaterials ・ PMID 41435455
in vitro
positive
animal study
Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling.
2026 ・ Bioact Mater ・ PMID 41334374
in vitro
positive
in vitro study
Advances in hydrogen delivery strategies for therapeutic applications.
2026 ・ Adv Drug Deliv Rev ・ PMID 41232804
mixed routes
not assessed
review
Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota.
2026 ・ Bone ・ PMID 41224067
hydrogen-rich water
positive
animal study
Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy.
2026 ・ Pain ・ PMID 41143867
hydrogen-rich water
positive
animal study
Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice.
2025 ・ J Tradit Chin Med ・ PMID 41376217
injection / infusion
positive
animal study
Efficacy of different nasal irrigation treatments versus placebo in allergic rhinitis: a systematic review and network meta-analysis.
2025 ・ Front Pharmacol ・ PMID 41293244
topical application
mixed
meta-analysis
Innovations in peritoneal dialysis fluid: biocompatible formulations and expanded therapeutic applications.
2025 ・ Ren Fail ・ PMID 41285129
not specified
not assessed
review
A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation.
2025 ・ In Vivo ・ PMID 41167690
not specified
mixed
human case report
Dynamic Immunomodulation by Hydrogen Capsule Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report.
2025 ・ In Vivo ・ PMID 41167678
hydrogen-rich water
positive
human case report
Molecular hydrogen-rhodiola as an adjuvant therapy for ischemic stroke in internal carotid artery occlusion: A case report.
2025 ・ Open Med (Wars) ・ PMID 41141928
hydrogen-rich water
positive
human case report
Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.
2025 ・ J Control Release ・ PMID 41083007
topical application
positive
animal study
Gut microbiota as a central mediator in hydrogen gas-induced alleviation of colitis via TLR4/NF-κB and Nrf2 pathway regulation.
2025 ・ Int Immunopharmacol ・ PMID 41076929
inhalation
positive
animal study
Adjunctive molecular hydrogen therapy for refractory malar rash in systemic lupus erythematosus: A case report with immunological insights.
2025 ・ SAGE Open Med Case Rep ・ PMID 40964664
hydrogen-rich water
positive
human case report
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