cGAS-STING経路の抑制を介した水素による乾癬様皮膚炎症の改善
Psoriasis is a chronic immune-mediated condition marked by keratinocyte hyperproliferation and dysregulated cytokine signaling. This study investigated the molecular basis by which hydrogen-rich water exerts its effects in psoriasis-like skin inflammation. The cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway was found to be activated in psoriatic lesions, and hydrogen administration markedly suppressed this pathway in both cell-based and mouse model experiments. Concurrently, expression of proliferative markers BCL2, BAX, and Ki-67 was reduced following hydrogen exposure. Reactive oxygen species levels and inflammatory cytokine production were also significantly diminished. These findings identify cGAS-STING pathway inhibition as a key mechanism underlying hydrogen's modulatory effects on keratinocyte proliferation and skin inflammation in psoriasis models.
Hydrogen-rich water inhibits the cGAS-STING signaling pathway, thereby reducing keratinocyte hyperproliferation and suppressing ROS generation along with inflammatory cytokine production in psoriasis-like inflammation.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/41533764