liver disease

56 papers

• Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling.
  2021 ・ Am J Physiol Gastrointest Liver Physiol ・ PMID 33439102
  hydrogen-rich water positive animal study
• Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats.
  2020 ・ Ann Agric Environ Med ・ PMID 32955216
  hydrogen-rich water positive animal study
• Inhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver resection.
  2019 ・ Ann Transl Med ・ PMID 32042790
  inhalation positive animal study
• Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters,-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver.
  2019 ・ Molecules ・ PMID 31330936
  hydrogen-rich water mixed animal study
• Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver dysfunction by restoring gap and tight junctions.
  2019 ・ Mol Med Rep ・ PMID 31059036
  animal model positive animal study
• Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial.
  2019 ・ Clin Res Hepatol Gastroenterol ・ PMID 30982748
  hydrogen-rich water positive human randomized controlled trial
• Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.
  2019 ・ BMC Gastroenterol ・ PMID 30736744
  injection / infusion positive animal study
• Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model.
  2018 ・ World J Gastroenterol ・ PMID 30568387
  hydrogen-rich water mixed animal study
• Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression.
  2018 ・ Sci Rep ・ PMID 30232347
  injection / infusion positive animal study
• Hydrogen Flush After Cold Storage as a New End-Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury.
  2018 ・ Liver Transpl ・ PMID 30120877
  injection / infusion positive animal study
• Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice.
  2018 ・ Med Gas Res ・ PMID 29770190
  hydrogen-rich water positive animal study
• Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles.
  2018 ・ Free Radic Res ・ PMID 29424253
  hydrogen-rich water positive meta-analysis
• Transplantation of High Hydrogen-Producing Microbiota Leads to Generation of Large Amounts of Colonic Hydrogen in Recipient Rats Fed High Amylose Maize Starch.
  2018 ・ Nutrients ・ PMID 29382125
  animal model positive animal study
• Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy.
  2017 ・ Mol Clin Oncol ・ PMID 29142752
  hydrogen-rich water positive human randomized controlled trial
• Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response.
  2017 ・ Biochem Biophys Res Commun ・ PMID 28890349
  animal model positive animal study
• Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice.
  2017 ・ World J Gastroenterol ・ PMID 28785146
  hydrogen-rich water positive animal study
• Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARα and PPARγ.
  2017 ・ Mol Med Rep ・ PMID 28098910
  injection / infusion positive animal study
• Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury.
  2017 ・ Shock ・ PMID 27918369
  hydrogen-rich water positive animal study
• Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model.
  2016 ・ Exp Ther Med ・ PMID 27284352
  inhalation positive animal study
• Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.
  2016 ・ Biochem Pharmacol ・ PMID 26774456
  hydrogen-rich water positive animal study
• Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression.
  2015 ・ Toxicol Lett ・ PMID 26276082
  in vitro positive in vitro study
• Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
  2015 ・ World J Gastroenterol ・ PMID 25892869
  hydrogen-rich water positive animal study
• Potential ghrelin-mediated benefits and risks of hydrogen water.
  2015 ・ Med Hypotheses ・ PMID 25649854
  hydrogen-rich water not assessed other
• Clusianone, a naturally occurring nemorosone regioisomer, uncouples rat liver mitochondria and induces HepG2 cell death.
  2014 ・ Chem Biol Interact ・ PMID 24491676
  in vitro positive in vitro study
• Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH).
  2013 ・ Int J Mol Sci ・ PMID 24132155
  hydrogen-rich water not assessed review