H₂
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mitochondrial function
226 papers
Delivery-method distribution
hydrogen-rich water: 55
in vitro: 46
mixed routes: 44
not specified: 34
inhalation: 24
injection / infusion: 15
animal model: 7
hydrogen bath: 1
Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions.
2021 ・ Curr Pharm Des ・ PMID 32767925
not specified
not assessed
review
Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through the Activation of PGC-α in Mice.
2021 ・ Shock ・ PMID 32590694
inhalation
positive
animal study
Inhaled Gases as Therapies for Post-Cardiac Arrest Syndrome: A Narrative Review of Recent Developments.
2020 ・ Front Med (Lausanne) ・ PMID 33585501
inhalation
not assessed
review
Two-week continuous supplementation of hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study.
2020 ・ Med Gas Res ・ PMID 33380582
hydrogen-rich water
mixed
human randomized controlled trial
Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems.
2020 ・ Antioxidants (Basel) ・ PMID 33333951
mixed routes
not assessed
review
The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity.
2020 ・ Curr Genomics ・ PMID 33214768
not specified
not assessed
review
Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study.
2020 ・ Med Gas Res ・ PMID 33004705
inhalation
positive
human randomized controlled trial
Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats.
2020 ・ Ann Agric Environ Med ・ PMID 32955216
hydrogen-rich water
positive
animal study
Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application.
2020 ・ Curr Opin Anaesthesiol ・ PMID 32826628
mixed routes
not assessed
review
Pharmacokinetics of a single inhalation of hydrogen gas in pigs.
2020 ・ PLoS One ・ PMID 32559239
inhalation
not assessed
animal study
Metabolomics Analysis of the Effect of Hydrogen-Rich Water on Myocardial Ischemia-Reperfusion Injury in Rats.
2020 ・ J Bioenerg Biomembr ・ PMID 32472432
hydrogen-rich water
positive
animal study
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats.
2020 ・ Int J Oral Maxillofac Surg ・ PMID 32451233
mixed routes
positive
animal study
Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling.
2020 ・ J Invest Dermatol ・ PMID 32234461
in vitro
positive
in vitro study
A "philosophical molecule," hydrogen may overcome senescence and intractable diseases.
2020 ・ Med Gas Res ・ PMID 32189669
inhalation
not assessed
review
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway.
2020 ・ Int Immunopharmacol ・ PMID 32058932
inhalation
positive
animal study
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
2020 ・ Sci Rep ・ PMID 32029879
mixed routes
positive
human observational study
Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.
2020 ・ Microbiol Mol Biol Rev ・ PMID 31996394
not specified
not assessed
review
Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal dialysis-related peritoneal fibrosis.
2020 ・ FASEB J ・ PMID 31930571
injection / infusion
positive
animal study
Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.
2020 ・ BMC Cancer ・ PMID 31924176
hydrogen-rich water
positive
animal study
Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential.
2020 ・ Biochem Biophys Res Commun ・ PMID 31810604
in vitro
positive
in vitro study
Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats.
2020 ・ Mol Med Rep ・ PMID 31746358
injection / infusion
positive
animal study
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury.
2020 ・ Curr Mol Med ・ PMID 31702499
hydrogen-rich water
positive
animal study
A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats.
2020 ・ Can J Physiol Pharmacol ・ PMID 31536712
hydrogen-rich water
positive
animal study
L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet.
2019 ・ Nutrients ・ PMID 31847305
hydrogen-rich water
positive
animal study
Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases.
2019 ・ Acta Biochim Biophys Sin (Shanghai) ・ PMID 31738389
not specified
not assessed
review
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