neuroinflammation

3 papers

Research evidence summary

Q: Does molecular hydrogen help with neuroinflammation?

A: Of 3 peer-reviewed papers, 2 reported a positive effect (the most common), 0 limited/mixed, 0 negative, 1 not assessed. Study mix: 0 human (0 RCT), 2 animal/basic, 1 meta-analysis or synthesis. The most studied delivery route is mixed routes. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	0	of which RCT	0
Animal/basic	2	Synthesis/meta	1
Reported effect	positive 2 ・ limited/mixed 0 ・ negative 0 ・ not assessed 1

Read the safety notes →

Delivery-method distribution

mixed routes: 2 inhalation: 1

Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
2026 ・ J Transl Med ・ PMID 41654898

mixed routes positive animal study
Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer's Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation-Fantasy or Reality?
2022 ・ Int J Mol Sci ・ PMID 35743035

mixed routes not assessed review
Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis.
2014 ・ Brain Res ・ PMID 25251596

inhalation positive animal study