ケイ酸マグネシウムナノシートによる持続的水素放出が脳内出血後の二次性脳損傷を軽減する
Intracerebral hemorrhage (ICH) causes severe secondary brain injury through oxidative stress, neuroinflammation, and apoptosis. This study synthesized pH-responsive magnesium silicate nanosheets (MGNs) capable of sustained hydrogen release, especially under acidic conditions. In a collagenase-induced ICH mouse model, oral MGN administration produced dose-dependent improvements in neurological function, reductions in brain edema and hematoma volume, preservation of neuronal integrity, suppression of pro-inflammatory cytokines, and decreased apoptotic signaling. MGNs outperformed conventional 3% hydrogen gas inhalation in neuroprotective efficacy and demonstrated a favorable biosafety profile across systematic evaluation. These findings position MGNs as a promising nanoplatform for sustained hydrogen delivery in the context of hemorrhagic brain injury.
MGNs release hydrogen continuously under acidic conditions, suppressing neuronal apoptotic pathways and reducing pro-inflammatory cytokine production, thereby mitigating secondary brain injury following ICH.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/41654898