H₂
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arthritis / rheumatism
24 papers
Delivery-method distribution
mixed routes: 7
hydrogen-rich water: 5
in vitro: 4
not specified: 3
injection / infusion: 2
hydrogen bath: 2
inhalation: 1
Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis.
2026 ・ World J Orthop ・ PMID 41608485
mixed routes
positive
review
Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report.
2026 ・ In Vivo ・ PMID 41482402
hydrogen-rich water
positive
human case report
A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation.
2025 ・ In Vivo ・ PMID 41167690
not specified
mixed
human case report
Predicting Therapeutic Response to Molecular Hydrogen in Autoimmune Diseases via Immunophenotyping.
2025 ・ APMIS ・ PMID 40590161
hydrogen-rich water
mixed
human observational study
Molecular Hydrogen Therapy in Rheumatoid Arthritis: A Case Report on the Amelioration of Methotrexate-induced Myelosuppression and Immune Modulation.
2025 ・ In Vivo ・ PMID 40579028
not specified
positive
human case report
Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized controlled trial.
2025 ・ Front Pharmacol ・ PMID 39950118
inhalation
mixed
human randomized controlled trial
Au/Ag@ZnS yolk-shell photocatalysts enhanced with noble metals and hyaluronic acid for efficient hydrogen production in rheumatoid arthritis therapy.
2024 ・ Int J Biol Macromol ・ PMID 39322151
in vitro
positive
in vitro study
Using oral molecular hydrogen supplements to combat microinflammation in humans: a pilot observational study.
2024 ・ Int J Med Sci ・ PMID 39310256
hydrogen-rich water
positive
human observational study
Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum.
2022 ・ Med Gas Res ・ PMID 34854419
hydrogen bath
positive
human observational study
Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete.
2020 ・ F1000Res ・ PMID 32399209
hydrogen bath
positive
human case report
Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis.
2020 ・ Med Sci Monit ・ PMID 31927559
injection / infusion
positive
animal study
Effect of Htreatment in a mouse model of rheumatoid arthritis-associated interstitial lung disease.
2019 ・ J Cell Mol Med ・ PMID 31424157
hydrogen-rich water
positive
animal study
Crystal structure of an apremilast ethanol hemisolvate hemihydrate solvatomorph.
2017 ・ Acta Crystallogr E Crystallogr Commun ・ PMID 28638635
not specified
not assessed
other
Should hydrogen therapy be included in a musculoskeletal medicine routine?
2016 ・ F1000Res ・ PMID 28003879
mixed routes
not assessed
review
Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress.
2016 ・ Am J Transl Res ・ PMID 27830032
in vitro
positive
animal study
Molecular hydrogen suppresses activated Wnt/β-catenin signaling.
2016 ・ Sci Rep ・ PMID 27558955
mixed routes
positive
in vitro study
Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.
2015 ・ Mol Med Rep ・ PMID 25936373
mixed routes
positive
human case report
Molecular hydrogen in sports medicine: new therapeutic perspectives.
2015 ・ Int J Sports Med ・ PMID 25525953
mixed routes
not assessed
review
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
2014 ・ Int Immunopharmacol ・ PMID 24929023
injection / infusion
positive
human randomized controlled trial
Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases.
2013 ・ Curr Pharm Des ・ PMID 23859555
mixed routes
not assessed
review
Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast.
2013 ・ Mol Cell Biochem ・ PMID 23212446
in vitro
positive
in vitro study
Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.
2012 ・ Med Gas Res ・ PMID 23031079
hydrogen-rich water
positive
human observational study
Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.
2011 ・ Med Gas Res ・ PMID 22146365
in vitro
positive
in vitro study
Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophages.
2011 ・ Biochem Biophys Res Commun ・ PMID 21723254
mixed routes
positive
in vitro study