関節リウマチおよび関連疾患における分子状水素の抗酸化・抗炎症作用に関するレビュー
Rheumatoid arthritis (RA) is a chronic inflammatory condition characterized by progressive joint destruction and an elevated risk of atherosclerosis leading to cardiovascular complications. Reactive oxygen species (ROS), particularly the hydroxyl radical, occupy a central position in RA pathogenesis by acting both upstream and downstream of the NF-κB and TNFα signaling pathways. Molecular hydrogen (H2) selectively neutralizes the hydroxyl radical and has been reported to reduce oxidative stress in RA patients when used alongside conventional interventions. This review examines the evidence supporting H2 administration in RA, highlighting its potential in early-stage disease where it may also aid diagnostic decision-making. Additional discussion covers the possible role of H2 in preventing RA-associated atherosclerosis and in mitigating inflammation-driven oxidative damage more broadly.
H2 selectively scavenges hydroxyl radicals, thereby reducing oxidative stress that operates both upstream and downstream of the NF-κB and TNFα inflammatory signaling pathways implicated in RA pathogenesis.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/23859555