hypertension

20 papers

Research evidence summary

Q: Does molecular hydrogen help with hypertension?

A: Of 20 peer-reviewed papers, 17 reported a positive effect (the most common), 2 limited/mixed, 0 negative, 1 not assessed. Study mix: 6 human (1 RCT), 13 animal/basic, 1 meta-analysis or synthesis. The most studied delivery route is hydrogen-rich water. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	6	of which RCT	1
Animal/basic	13	Synthesis/meta	1
Reported effect	positive 17 ・ limited/mixed 2 ・ negative 0 ・ not assessed 1

Read the safety notes →

Delivery-method distribution

hydrogen-rich water: 8 inhalation: 6 injection / infusion: 3 mixed routes: 2 in vitro: 1

Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension.
2026 ・ Biomedicines ・ PMID 41898141

inhalation positive animal study
Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.
2026 ・ In Vivo ・ PMID 41482388

hydrogen-rich water positive human case report
Therapeutic potential of magnesium diboride nanosheets in PAH-associated right heart failure: Integrated multi-omics analysis reveals ferroptosis suppression via LC3/ATG5/NCOA4/FTH1 pathway.
2026 ・ Free Radic Biol Med ・ PMID 41308938

in vitro positive animal study
Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models: A Review.
2025 ・ Int J Mol Sci ・ PMID 41373725

mixed routes not assessed review
[Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period].
2025 ・ Ter Arkh ・ PMID 40327618

inhalation positive human randomized controlled trial
Molecular Hydrogen Therapy in Sjögren's Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell.
2024 ・ In Vivo ・ PMID 39477378

hydrogen-rich water positive human case report
The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension.
2024 ・ Int J Mol Sci ・ PMID 39456794

inhalation positive animal study
Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
2023 ・ Biomedicines ・ PMID 38137362

inhalation mixed animal study
Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study.
2023 ・ Front Nutr ・ PMID 37521410

hydrogen-rich water mixed human case report
Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats.
2022 ・ Exp Anim ・ PMID 35264492

hydrogen-rich water positive animal study
Attenuation of Myocardial Fibrosis Using Molecular Hydrogen by Inhibiting the TGF-β Signaling Pathway in Spontaneous Hypertensive Rats.
2022 ・ Am J Hypertens ・ PMID 34618887

injection / infusion positive animal study
Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension.
2020 ・ Sci Rep ・ PMID 33244027

inhalation positive animal study
Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic nerve activity and increasing vasodilator responses via the antioxidation.
2019 ・ J Cell Biochem ・ PMID 30259991

inhalation positive animal study
Novel haemodialysis (HD) treatment employing molecular hydrogen (H)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.
2018 ・ Sci Rep ・ PMID 29321509

injection / infusion positive human observational study
Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation.
2017 ・ PLoS One ・ PMID 28902900

injection / infusion positive human observational study
Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via Down-Regulation of Mitogen/Activated Protein Kinase and Ezrin-Radixin-Moesin Signaling Pathways.
2016 ・ Chin J Physiol ・ PMID 26875562

mixed routes positive in vitro study
Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects.
2015 ・ J Thorac Cardiovasc Surg ・ PMID 26095621

hydrogen-rich water positive animal study
Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
2015 ・ BMC Neurosci ・ PMID 25925889

hydrogen-rich water positive animal study
Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats.
2014 ・ Mol Cell Biochem ・ PMID 24652103

hydrogen-rich water positive animal study
Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model.
2011 ・ Med Gas Res ・ PMID 22146083

hydrogen-rich water positive animal study