Parkinson's disease

30 papers

Research evidence summary

Q: Does molecular hydrogen help with Parkinson's disease?

A: Of 30 peer-reviewed papers, 8 reported a positive effect, 1 limited/mixed, 2 negative, 19 not assessed. Study mix: 5 human (3 RCT), 7 animal/basic, 16 meta-analysis or synthesis. The most studied delivery route is mixed routes. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	5	of which RCT	3
Animal/basic	7	Synthesis/meta	16
Reported effect	positive 8 ・ limited/mixed 1 ・ negative 2 ・ not assessed 19

Read the safety notes →

Delivery-method distribution

mixed routes: 9 hydrogen-rich water: 9 not specified: 6 inhalation: 3 in vitro: 2 topical application: 1

Silicon Nanostructures for Hydrogen Generation and Storage.
2025 ・ Nanomaterials (Basel) ・ PMID 41090875

not specified not assessed review
Role and mechanism of molecular hydrogen in the treatment of Parkinson's diseases.
2025 ・ Front Neurosci ・ PMID 40336538

mixed routes mixed review
Hydrogen as an innovative nootropic in health and disease.
2025 ・ Nutr Health ・ PMID 39042916

mixed routes not assessed review
Realizing brain therapy with "smart medicine": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.
2024 ・ Med Gas Res ・ PMID 39073335

inhalation positive human case report
Theoretical investigations of free energy of binding and chiral recognition studies of (R)- and (S)-Noradrenaline towards β-cyclodextrin.
2023 ・ J Mol Graph Model ・ PMID 37379759

in vitro not assessed in vitro study
Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity.
2023 ・ Antioxidants (Basel) ・ PMID 37237854

mixed routes not assessed review
Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.
2023 ・ Mol Neurobiol ・ PMID 36567361

mixed routes not assessed review
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries.
2023 ・ Curr Top Med Chem ・ PMID 36529921

topical application not assessed review
Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a pilot study.
2021 ・ Neurol Sci ・ PMID 34319514

inhalation null human randomized controlled trial
Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study.
2021 ・ Medicine (Baltimore) ・ PMID 33530211

mixed routes positive human case report
Molecular hydrogen (H) as a potential treatment for acute and chronic fatigue.
2021 ・ Arch Pharm (Weinheim) ・ PMID 33368699

not specified not assessed review
Neuroprotective Effects of Molecular Hydrogen: A Critical Review.
2021 ・ Neurosci Bull ・ PMID 33078374

mixed routes not assessed review
Neuroprotective and Preventative Effects of Molecular Hydrogen.
2021 ・ Curr Pharm Des ・ PMID 33076798

hydrogen-rich water not assessed review
Circulating messenger for neuroprotection induced by molecular hydrogen.
2019 ・ Can J Physiol Pharmacol ・ PMID 31100203

hydrogen-rich water not assessed review
Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease.
2018 ・ Med Gas Res ・ PMID 30713666

inhalation null human randomized controlled trial
Inadequate Production of Hby Gut Microbiota and Parkinson Disease.
2018 ・ Trends Endocrinol Metab ・ PMID 29478695

not specified not assessed review
Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration.
2017 ・ J Clin Biochem Nutr ・ PMID 28751802

mixed routes not assessed review
Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson's Disease Model Mice.
2017 ・ Neurochem Res ・ PMID 28462451

hydrogen-rich water positive animal study
A comprehensive computational study on pathogenic mis-sense mutations spanning the RING2 and REP domains of Parkin protein.
2017 ・ Gene ・ PMID 28189762

in vitro not assessed in vitro study
Molecular Hydrogen as a Neuroprotective Agent.
2017 ・ Curr Neuropharmacol ・ PMID 27281176

mixed routes not assessed review
Potential ghrelin-mediated benefits and risks of hydrogen water.
2015 ・ Med Hypotheses ・ PMID 25649854

hydrogen-rich water not assessed other
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
2014 ・ PLoS One ・ PMID 25251220

hydrogen-rich water positive animal study
Parkinson's disease may be due to failure of melanin in the Substantia Nigra to produce molecular hydrogen from dissociation of water, to protect the brain from oxidative stress.
2014 ・ Med Hypotheses ・ PMID 24529916

not specified not assessed other
Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice.
2013 ・ Sci Rep ・ PMID 24253616

hydrogen-rich water positive animal study
Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.
2013 ・ Med Gas Res ・ PMID 23742229

not specified not assessed review