Parkinson's disease

30 papers

Research evidence summary

Q: Does molecular hydrogen help with Parkinson's disease?

A: Of 30 peer-reviewed papers, 8 reported a positive effect, 1 limited/mixed, 2 negative, 19 not assessed. Study mix: 5 human (3 RCT), 7 animal/basic, 16 meta-analysis or synthesis. The most studied delivery route is mixed routes. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	5	of which RCT	3
Animal/basic	7	Synthesis/meta	16
Reported effect	positive 8 ・ limited/mixed 1 ・ negative 2 ・ not assessed 19

Read the safety notes →

Delivery-method distribution

mixed routes: 9 hydrogen-rich water: 9 not specified: 6 inhalation: 3 in vitro: 2 topical application: 1

Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
2013 ・ Mov Disord ・ PMID 23400965

hydrogen-rich water positive human randomized controlled trial
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.
2012 ・ Oxid Med Cell Longev ・ PMID 22720117

mixed routes not assessed review
Therapeutic effects of hydrogen in animal models of Parkinson's disease.
2011 ・ Parkinsons Dis ・ PMID 21687749

not specified not assessed review
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
2009 ・ PLoS One ・ PMID 19789628

hydrogen-rich water positive animal study
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.
2009 ・ Neurosci Lett ・ PMID 19356598

hydrogen-rich water positive animal study