健康および疾患における革新的な認知機能向上物質としての水素の可能性
Molecular hydrogen (H2) functions as both an antioxidant and a signaling molecule, exhibiting antiapoptotic and anti-inflammatory properties in addition to its antioxidative effects. This review examines the current state of evidence regarding H2 as a nootropic agent capable of enhancing cognitive performance. Although human studies remain limited in number, available clinical data indicate improvements in executive function, alertness, and memory across diverse populations—including healthy young adults, older individuals, those with disrupted circadian rhythms, patients with neurodegenerative conditions, and cancer patients. The review outlines proposed mechanisms of action and identifies gaps requiring further investigation before definitive conclusions can be drawn about H2's role in cognitive enhancement.
H2 is proposed to protect neurons through antioxidative, antiapoptotic, and anti-inflammatory pathways, thereby supporting improvements in executive function, alertness, and memory across various clinical populations.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39042916