分子状水素はサリチル酸シグナル経路を介してイネ縞葉枯ウイルスへの抵抗性を付与する
Following rice stripe virus (RSV) infection, endogenous H2 production was markedly elevated in the resistant rice cultivar Zhendao 88 relative to the susceptible cultivar Wuyujing No.3. Exogenous H2 application reduced disease severity and coat protein (CP) accumulation, most prominently in the susceptible variety, while pharmacological blockade of H2 production abolished these effects. Transgenic Arabidopsis plants overexpressing a bacterial hydrogenase gene also showed improved resistance. Mechanistically, H2 promoted transcription of salicylic acid (SA) biosynthetic genes and suppressed SA glucosyltransferase activity, collectively increasing SA levels. SA biosynthetic mutants exhibited heightened susceptibility to RSV and did not respond to H2 supplementation, indicating that the SA-dependent signaling pathway is required for H2-mediated resistance. These findings suggest a potential role for H2 in plant pathogen defense.
H2 upregulates salicylic acid (SA) biosynthetic gene transcription and suppresses SA glucosyltransferase activity, leading to SA accumulation and activation of the SA-dependent plant defense signaling pathway against RSV infection.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/36840556