graft-versus-host disease

5 papers

Research evidence summary

Q: Does molecular hydrogen help with graft-versus-host disease?

A: Of 5 peer-reviewed papers, 5 reported a positive effect (the most common), 0 limited/mixed, 0 negative, 0 not assessed. Study mix: 2 human (0 RCT), 3 animal/basic, 0 meta-analysis or synthesis. The most studied delivery route is hydrogen-rich water. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	2	of which RCT	0
Animal/basic	3	Synthesis/meta	0
Reported effect	positive 5 ・ limited/mixed 0 ・ negative 0 ・ not assessed 0

Read the safety notes →

Delivery-method distribution

hydrogen-rich water: 4 injection / infusion: 1

Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation.
2021 ・ Oxid Med Cell Longev ・ PMID 34691352

hydrogen-rich water positive animal study
Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial.
2020 ・ Front Immunol ・ PMID 33324415

hydrogen-rich water positive human observational study
Therapeutic effects of hydrogen on chronic graft-versus-host disease.
2017 ・ J Cell Mol Med ・ PMID 28374556

injection / infusion positive animal study
Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.
2016 ・ Med Gas Res ・ PMID 27867488

hydrogen-rich water positive human case report
Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.
2012 ・ Transpl Int ・ PMID 22891787

hydrogen-rich water positive animal study