水素が慢性移植片対宿主病に及ぼす効果：マウスモデルを用いた検討
Chronic graft-versus-host disease (cGVHD) represents a leading cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation, with inflammatory cytokine dysregulation and fibrosis as central pathogenic drivers. Using an MHC-incompatible murine bone marrow transplantation model, this study examined whether hydrogen-rich saline administration could mitigate cGVHD. Survival rates and skin lesion severity were monitored after transplantation. Mice receiving hydrogen-rich saline showed improved survival and reduced skin pathology compared with controls. These findings extend prior observations on hydrogen in acute GVHD to the chronic form, suggesting that the anti-inflammatory, antioxidant, and anti-fibrotic properties of molecular hydrogen may contribute to beneficial outcomes in cGVHD.
Molecular hydrogen is proposed to suppress cGVHD pathology by counteracting inflammatory cytokine imbalance and tissue fibrosis through its anti-inflammatory, antioxidant, and anti-fibrotic properties.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/28374556