Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.

Abstract

Chronic graft-versus-host disease (cGVHD) is a serious complication following allogeneic hematopoietic stem cell transplantation, with inflammation and fibrosis identified as central pathogenic mechanisms. Molecular hydrogen possesses anti-inflammatory, antioxidant, and anti-fibrotic properties, suggesting potential relevance to cGVHD pathophysiology. This case report describes a patient with severe cGVHD who consumed hydrogen-rich water and experienced notable clinical improvement. The authors propose that oral intake of hydrogen-rich water may represent a safe and potentially beneficial approach for managing this difficult condition, warranting further investigation in controlled settings.

Mechanism

Molecular hydrogen's anti-inflammatory, antioxidant, and anti-fibrotic properties may suppress the inflammation and fibrosis that underlie cGVHD pathogenesis.