水素豊富水摂取による慢性移植片対宿主病の1症例報告
Chronic graft-versus-host disease (cGVHD) is a serious complication following allogeneic hematopoietic stem cell transplantation, with inflammation and fibrosis identified as central pathogenic mechanisms. Molecular hydrogen possesses anti-inflammatory, antioxidant, and anti-fibrotic properties, suggesting potential relevance to cGVHD pathophysiology. This case report describes a patient with severe cGVHD who consumed hydrogen-rich water and experienced notable clinical improvement. The authors propose that oral intake of hydrogen-rich water may represent a safe and potentially beneficial approach for managing this difficult condition, warranting further investigation in controlled settings.
Molecular hydrogen's anti-inflammatory, antioxidant, and anti-fibrotic properties may suppress the inflammation and fibrosis that underlie cGVHD pathogenesis.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/27867488