水素含有飲料水による心臓同種移植片の炎症関連障害に対する保護効果
Using rat models of heterotopic cardiac transplantation with short-course tacrolimus immunosuppression and orthotopic aortic transplantation, this study examined the effects of daily consumption of hydrogen-rich water (HW) prepared by either magnesium-stick reaction or hydrogen gas bubbling. Compared with recipients given regular water or degassed water, those receiving HW showed markedly prolonged cardiac allograft survival and reduced intimal hyperplasia in transplanted aortas. In vitro experiments demonstrated that hydrogen suppressed T cell proliferation and decreased production of interleukin-2 and interferon-γ. Additionally, grafts from HW-treated animals exhibited elevated ATP concentrations and enhanced mitochondrial respiratory chain enzyme activity, suggesting that hydrogen may support graft energetics alongside its anti-inflammatory actions.
Hydrogen appears to protect allografts by suppressing T cell proliferation and reducing IL-2 and IFN-γ production, while simultaneously enhancing mitochondrial respiratory chain enzyme activity and increasing graft ATP levels, thereby combining immunomodulatory and bioenergetic effects.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/22891787