hydroxyl radical scavenging

352 papers

Research evidence summary

Q: Does molecular hydrogen help with hydroxyl radical scavenging?

A: Of 352 peer-reviewed papers, 220 reported a positive effect (the most common), 23 limited/mixed, 3 negative, 106 not assessed. Study mix: 43 human (23 RCT), 195 animal/basic, 94 meta-analysis or synthesis. The most studied delivery route is hydrogen-rich water. The above aggregates published research and does not constitute a clinically established conclusion. See the individual paper pages for details and Safety notes for inhalation safety. (last updated 2026-05-15)

Evidence breakdown
Human	43	of which RCT	23
Animal/basic	195	Synthesis/meta	94
Reported effect	positive 220 ・ limited/mixed 23 ・ negative 3 ・ not assessed 106

Read the safety notes →

Delivery-method distribution

hydrogen-rich water: 93 mixed routes: 71 inhalation: 66 in vitro: 41 injection / infusion: 34 not specified: 31 topical application: 9 animal model: 7

Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study.
2024 ・ Biomedicines ・ PMID 39200347

in vitro positive in vitro study
The Landscape of Smart Biomaterial-Based Hydrogen Therapy.
2024 ・ Adv Sci (Weinh) ・ PMID 39166484

mixed routes not assessed review
Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.
2024 ・ Crit Care Med ・ PMID 39133068

inhalation mixed human randomized controlled trial
Effects of Molecular Hydrogen in the Pathophysiology and Management of Cardiovascular and Metabolic Diseases.
2024 ・ Rev Cardiovasc Med ・ PMID 39077646

mixed routes not assessed review
Realizing brain therapy with "smart medicine": mechanism and case report of molecular hydrogen inhalation for Parkinson's disease.
2024 ・ Med Gas Res ・ PMID 39073335

inhalation positive human case report
Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation.
2024 ・ Biomedicines ・ PMID 39062164

mixed routes not assessed review
Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes.
2024 ・ J Cell Mol Med ・ PMID 39001579

hydrogen-rich water positive animal study
The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study.
2024 ・ Free Radic Biol Med ・ PMID 38996821

inhalation positive human randomized controlled trial
A Novel Antioxidant, Hydrogen-Rich Coral Calcium Alters Gut Microbiome and Bile Acid Synthesis to Improve Methionine-and-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease.
2024 ・ Antioxidants (Basel) ・ PMID 38929185

animal model positive animal study
Mitigating radiation-induced brain injury via NLRP3/NLRC4/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water.
2024 ・ Biomed Pharmacother ・ PMID 38906028

hydrogen-rich water positive animal study
Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway.
2024 ・ World J Gastroenterol ・ PMID 38855154

hydrogen-rich water positive animal study
Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease.
2024 ・ Biomed Pharmacother ・ PMID 38795643

mixed routes not assessed review
Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats.
2024 ・ Sci Rep ・ PMID 38745034

mixed routes positive animal study
Combined use of hydrogen-rich water and enzyme-digested edible bird's nest improves PMA/LPS-impaired wound healing in human inflammatory gingival tissue equivalents.
2024 ・ Hum Cell ・ PMID 38679666

in vitro positive in vitro study
Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis.
2024 ・ Front Nutr ・ PMID 38590828

mixed routes mixed meta-analysis
Prospects of molecular hydrogen in cancer prevention and treatment.
2024 ・ J Cancer Res Clin Oncol ・ PMID 38555538

mixed routes not assessed review
Health Benefits of Electrolyzed Hydrogen Water: Antioxidant and Anti-Inflammatory Effects in Living Organisms.
2024 ・ Antioxidants (Basel) ・ PMID 38539846

hydrogen-rich water not assessed review
Mechanistic study of the electrochemical oxidation of fluoroquinolones: Ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin.
2024 ・ Chemosphere ・ PMID 38522672

not specified not assessed other
Hydrogen inhalation: in vivo rat genotoxicity tests.
2024 ・ Mutat Res Genet Toxicol Environ Mutagen ・ PMID 38432775

inhalation null animal study
Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing.
2024 ・ Natl Sci Rev ・ PMID 38213516

topical application positive animal study
Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats.
2023 ・ Biomedicines ・ PMID 38137362

inhalation mixed animal study
Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes.
2023 ・ Molecules ・ PMID 38067515

mixed routes positive review
Hyperbaric hydrogen therapy improves secondary brain injury after head trauma.
2023 ・ Undersea Hyperb Med ・ PMID 38055881

inhalation positive animal study
Novel Role of Molecular Hydrogen: The End of Ophthalmic Diseases?
2023 ・ Pharmaceuticals (Basel) ・ PMID 38004433

mixed routes not assessed review
Clinical Use and Treatment Mechanism of Molecular Hydrogen in the Treatment of Various Kidney Diseases including Diabetic Kidney Disease.
2023 ・ Biomedicines ・ PMID 37893190

mixed routes not assessed review