心血管疾患および代謝性疾患の病態生理と管理における分子状水素の役割に関するレビュー
Western dietary patterns promote oxidative stress and inflammation, increasing risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), whereas Mediterranean-style diets rich in antioxidants appear protective. Gut fermentation of dietary fiber, flavonoids, and probiotics generates substantial volumes of molecular hydrogen (H2), which acts as an endogenous antioxidant by scavenging free radicals and suppressing inflammatory signaling. Over the past two decades, accumulating evidence from both experimental and clinical studies indicates that H2—whether produced endogenously or administered exogenously via inhalation or hydrogen-rich water—exerts broad anti-inflammatory and antioxidant effects. H2 selectively neutralizes hydroxyl and nitrosyl radicals, reducing cellular oxidative burden. This review synthesizes current evidence on how H2 influences CVD and metabolic disease pathophysiology, noting that while existing data are promising, larger-scale clinical investigations are needed to confirm the magnitude of these effects.
H2 selectively scavenges hydroxyl and nitrosyl radicals, reducing intracellular oxidative stress and dampening inflammatory signaling pathways, thereby attenuating pathophysiological progression in cardiovascular and metabolic conditions.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39077646