スマートバイオマテリアルを基盤とした水素デリバリーシステムの研究動向
This review systematically examines biomaterial-based strategies for delivering molecular hydrogen, addressing the fundamental limitation that systemic H2 gas administration fails to achieve sufficient local concentrations at target lesion sites. The authors outline the historical development of biomaterial-based hydrogen carriers, stimuli-responsive release mechanisms, and underlying therapeutic pathways. Hydrogen generated from these biomaterials demonstrates multiple modes of action: scavenging reactive oxygen species (ROS) and suppressing lipid peroxidation (LPO), inhibiting disease-initiating danger signals such as pro-inflammatory cytokines, adenosine triphosphate (ATP), and heat shock proteins (HSP), and functioning as signaling molecules to modulate key regulatory pathways. The review also evaluates current opportunities and obstacles in this field and highlights priority directions for translating biomaterial-based hydrogen delivery into clinical practice.
Hydrogen released from biomaterials scavenges ROS and suppresses lipid peroxidation, inhibits pro-inflammatory cytokines, ATP, and heat shock proteins, and acts as a signaling molecule to regulate key disease-associated pathways.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/39166484