各種投与経路による水素投与後のラット組織内水素濃度の推定：気密チューブを用いた新規測定法
This study examined hydrogen concentration dynamics in Wistar rat blood and organ tissues following four distinct delivery routes: oral hydrogen super-rich water, intraperitoneal hydrogen super-rich saline, intravenous hydrogen super-rich saline, and inhaled hydrogen gas. A newly developed measurement approach combined high-sensitivity sensor gas chromatography with tissue homogenization performed inside airtight tubes, enabling stable and precise quantification. Peak hydrogen concentrations were observed at 5 minutes post-administration for oral and intraperitoneal routes, whereas intravenous delivery produced a peak at 1 minute. Inhalation resulted in a significant and sustained elevation beginning at 30 minutes. These findings establish a reliable analytical framework for characterizing hydrogen pharmacokinetics across tissues, which may inform the design of future experimental and clinical investigations involving molecular hydrogen.
Hydrogen concentration kinetics in rat tissues vary by delivery route: intravenous administration produces the fastest peak at 1 minute, oral and intraperitoneal routes peak at 5 minutes, and inhalation yields a sustained elevation from 30 minutes onward, reflecting differences in absorption and distribution pathways.
This study combines multiple delivery routes. As a general principle, the most efficient route for routine hydrogen intake is inhalation. Inhalation carries explosion risk (empirical LFL of 10%; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/24975958