出血性ショックにおけるREBOA使用下での大動脈内灌流による腸管への水素分子送達：概念実証研究
During hemorrhagic shock management with resuscitative endovascular balloon occlusion of the aorta (REBOA), blood flow distal to the balloon is interrupted, preventing systemically administered hydrogen from reaching ischemic organs. Using a 40 kg female swine model, this proof-of-concept study evaluated whether hydrogen-dissolved saline infused through a catheter placed distal to the REBOA balloon could deliver hydrogen to the intestine. Portal vein hydrogen concentrations were measured across four experimental conditions: controlled hemorrhagic shock with full REBOA occlusion yielded 0.224 mg/L (13.998%); uncontrolled hemorrhagic shock with liver injury under full occlusion yielded 0.049 mg/L (3.063%); the same uncontrolled model with partial occlusion yielded 0.018 mg/L (1.125%); and the saline-only control yielded 0.002 mg/L (0.015%). Detection of hydrogen in the portal vein across all active conditions confirms that intra-aortic irrigation can serve as a delivery route for hydrogen to the ischemic intestine during REBOA use, though clinical translation requires further study.
Infusing hydrogen-dissolved saline through an intra-aortic catheter positioned distal to the REBOA balloon allows hydrogen molecules to reach the intestinal vasculature and portal circulation even when systemic blood flow is occluded, potentially mitigating ischemic injury in the gut.
Intravenous hydrogen-saline infusion is a clinic-only route and is not viable for everyday self-administration. For routine hydrogen intake, inhalation is the most practical route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration 66% / 100% devices are not recommended).
See also:
https://h2-papers.org/en/papers/41751354