水素富化水浸漬がAeromonas hydrophila感染ゼブラフィッシュの自然免疫応答と生存率に及ぼす影響
This study examined the effects of hydrogen-rich water (HRW) immersion on zebrafish (Danio rerio) challenged with the pathogenic bacterium Aeromonas hydrophila. Fish subjected to HRW immersion showed improved post-infection survival rates compared to controls, and bacterial proliferation within the host was markedly reduced. Gene expression analysis in the spleen, kidney, and liver revealed downregulation of pro-inflammatory mediators including IL-1β, IL-6, and NF-κB, alongside upregulation of the anti-inflammatory cytokine IL-10. These findings represent the first investigation of HRW effects in bacterially infected fish and suggest potential applications of molecular hydrogen in aquaculture disease management.
HRW suppresses pro-inflammatory gene expression (NF-κB, IL-1β, IL-6) while upregulating the anti-inflammatory cytokine IL-10 in multiple organs, thereby modulating innate immune responses and limiting bacterial proliferation in zebrafish.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
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https://h2-papers.org/en/papers/28630014