H₂
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reactive oxygen species
774 papers
Delivery-method distribution
hydrogen-rich water: 224
in vitro: 135
inhalation: 133
mixed routes: 118
not specified: 75
injection / infusion: 58
topical application: 14
animal model: 12
hydrogen bath: 5
Inhalation of hydrogen gas reduces exacerbations of acute aortic dissection in mice.
2026 ・ Life Sci ・ PMID 42105975
inhalation
positive
animal study
Effects of Inhalation of Hydrogen Gas on Allergic Conjunctivitis Model Mice.
2026 ・ J Ocul Pharmacol Ther ・ PMID 42101321
inhalation
positive
animal study
Consumption of hydrogen-rich water ameliorates atherosclerosis by modulating gut microbiota and enhancing short-chain fatty acid levels.
2026 ・ Life Sci ・ PMID 42069299
hydrogen-rich water
positive
animal study
Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics.
2026 ・ Front Neurosci ・ PMID 42057900
not specified
not assessed
review
Adjunctive Molecular Hydrogen Capsule Therapy in Empyema Complicated by Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.
2026 ・ In Vivo ・ PMID 42049414
hydrogen-rich water
positive
human case report
Hydrogen gas inhalation alleviated cerebral ischemia/reperfusion injury by regulating mitophagy in SH-SY5Y cells and mice via PTEN-induced kinase 1/Parkin pathway.
2026 ・ J Stroke Cerebrovasc Dis ・ PMID 42049119
inhalation
positive
animal study
Molecular hydrogen suppresses gut inflammation and pyroptosis in ulcerative colitis through promoting PKM2 lactylation to block NLRP3 inflammasome activation.
2026 ・ Int Immunopharmacol ・ PMID 42035551
mixed routes
positive
animal study
Hydrogen-Rich Water as a Performance-Enhancing Aid in National-Level Finswimmers: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.
2026 ・ Int J Sports Physiol Perform ・ PMID 41991147
hydrogen-rich water
mixed
human randomized controlled trial
Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms.
2026 ・ Int J Mol Sci ・ PMID 41977237
hydrogen-rich water
positive
animal study
Status quo, challenges and future directions of hydrogen medicine.
2026 ・ Fundam Res ・ PMID 41971791
mixed routes
not assessed
review
An Iron-Scavenging and Hydrogen-Releasing Microneedle Patch Suppresses Ferroptosis and Promotes Spinal Cord Repair.
2026 ・ ACS Nano ・ PMID 41960786
topical application
positive
animal study
Molecular hydrogen as a treatment for ME/CFS: a mini-review of clinical evidence and mechanistic rationale.
2026 ・ Front Med (Lausanne) ・ PMID 41930109
hydrogen-rich water
positive
review
Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension.
2026 ・ Biomedicines ・ PMID 41898141
inhalation
positive
animal study
Neuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model.
2026 ・ Antioxidants (Basel) ・ PMID 41897548
inhalation
positive
animal study
Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.
2026 ・ Biochem Biophys Rep ・ PMID 41890216
hydrogen-rich water
positive
animal study
[The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome].
2026 ・ Ter Arkh ・ PMID 41859790
inhalation
positive
human randomized controlled trial
Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx.
2026 ・ Theranostics ・ PMID 41799190
inhalation
positive
in vitro study
Enhanced phytoremediation of Cd-As co-contaminated farmland using hydrogen-rich water: Mechanisms and efficiency evaluation in Solanum nigrum L․.
2026 ・ J Environ Sci (China) ・ PMID 41765536
hydrogen-rich water
positive
other
Adjunctive Molecular Hydrogen Therapy Modulates T Cell Markers and Reduces Anti-Ro Antibody in Refractory Oral Ulcers of Behçet's Disease and Sjögren's Syndrome: A Case Report.
2026 ・ In Vivo ・ PMID 41760342
hydrogen-rich water
positive
human case report
Molecular Hydrogen Improves Storage Quality of Bok Choy by Reducing Water Loss and Maintaining Cell Wall Integrity.
2026 ・ Plants (Basel) ・ PMID 41754355
in vitro
positive
other
Ru-Based NSAIDs as Potential Anticancer Therapeutics.
2026 ・ Molecules ・ PMID 41752368
in vitro
positive
in vitro study
Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury.
2026 ・ Antioxidants (Basel) ・ PMID 41750640
hydrogen-rich water
positive
animal study
Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model.
2026 ・ Geriatr Gerontol Int ・ PMID 41749059
in vitro
positive
in vitro study
The protective effects of molecular hydrogen in sepsis-associated encephalopathy: current status.
2026 ・ Eur J Pharmacol ・ PMID 41747800
mixed routes
not assessed
review
Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy.
2026 ・ J Cell Mol Med ・ PMID 41702867
in vitro
positive
in vitro study
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