発泡性水素発生錠剤の製剤設計と特性評価
Molecular hydrogen has attracted attention as a medical gas with potential applications in conditions involving inflammation and oxidative stress. Magnesium-containing effervescent tablets represent a viable oral delivery platform, since hydrogen is produced when magnesium reduces hydrogen ions in water. This study examined how various saccharide-based excipients influence the morphological characteristics, mechanical strength, and disintegration behavior of hydrogen-generating effervescent tablets manufactured by dry granulation. Among the saccharides evaluated, mannitol demonstrated superior performance, enabling rapid hydrogen generation while maintaining acceptable tablet hardness. Subsequent optimization of lubricant selection led to the adoption of adipic acid, chosen on the basis of regulatory acceptability. These findings provide a formulation framework for developing effervescent hydrogen-generating tablets suitable for oral use.
Hydrogen gas is produced via reduction of hydrogen ions by magnesium metal in aqueous solution. Mannitol as a saccharide excipient accelerates tablet disintegration, thereby enhancing the rate of hydrogen generation compared with other saccharides tested.
Hydrogen-rich water is a low-risk delivery route, but the achievable systemic hydrogen dose is bounded. For clinical applications, inhalation is the most efficient route; inhalation, however, carries explosion risk, and concentration matters (empirical LFL of 10% applies to inhalation environments; high-concentration devices are documented in the Consumer Affairs Agency accident database and are not recommended).
See also:
https://h2-papers.org/en/papers/34959728