血液透析応用に向けた水素富化水中の溶存水素定量および連続モニタリングの実験的検討
Oxidative and inflammatory stress is commonly observed in end-stage renal disease patients undergoing chronic haemodialysis, and hydrogen-enriched dialysate has been proposed as a potential countermeasure. This in vitro study investigated a contactless sensor system for quantifying dissolved molecular hydrogen in physiological solutions, assembling an experimental circuit to assess the sensitivity and accuracy of a hydrogen monitoring device. Dissolved hydrogen concentrations were cross-validated using an established oxygen sensor providing continuous partial pressure readings. A linear relationship was confirmed between the hydrogen fraction in the gas phase and the equilibrium dissolved hydrogen concentration. However, the monitoring system exhibited a relatively slow response time, and minor inter-sensor variability as well as temperature-dependent deviations were noted, suggesting that periodic recalibration may be warranted. These limitations were considered largely negligible for haemodialysis-related applications, supporting the feasibility of this measurement approach in clinical dialysis settings.
A linear relationship between the gaseous hydrogen fraction and equilibrium dissolved hydrogen concentration in physiological solutions was established, demonstrating the feasibility of continuous, contactless quantification of dissolved molecular hydrogen.
This is basic research at the cellular or molecular level. For human application, inhalation is the most promising delivery route, but inhalation carries explosion risk and concentration matters (empirical LFL of 10%; high-concentration devices are not recommended).
See also:
https://h2-papers.org/en/papers/35075943